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More than 20 years ago, in the preface to the first edition of the Textbook of Rheumatology, we suggested that "The field of rheumatology has come of age." What we meant was that rheumatology had shed its strictly empirical base and its host of unproven remedies and become a healing discipline thoroughly grounded in science. We thought it was time for a new textbook, one that reflected this passage through epistemological puberty.

The sixth edition reflects the maturation of rheumatology as a subspecialty. It is instructive to compare the contents of the first and sixth editions. Many chapters have disappeared entirely, and their material has been condensed and incorporated into existing chapters. Consider, for example, that in the basic science section of the first edition we devoted entire chapters to immunoglobulin structure, the contact activation system, and lysosomes (not to mention purine metabolism, a subject dear to the heart of the then senior editor). Cyclic nucleotides and eosinophilic chemotactic factor of anaphylaxis figured prominently in the titles of other basic science chapters. None of these has a place in the Table of Contents of the current edition. Instead, there are chapters dealing with dendritic cells, leukotrienes, mast cells, nitric oxide, fibroblasts, cytokines, and apoptosis. The importance of these topics to understanding the rheumatic diseases was unknown 20 years ago, and some of them hadn't even been discovered! Who can imagine what the scientific basis of rheumatology will be in the 10th edition, 20 years from now? Surely, knowledge obtained from the working through of the human genome will figure prominently.

VOLUME 1

Section 1 BIOLOGY OF THE NORMAL JOINT

1. BIOLOGY OF THE NORMAL JOINT

2. COLLAGEN AND ELASTIN

3. MATRIX GLYCOPROTEINS,PROTEOGLYCANS,AND CARTILAGE

4. PROTEINASES AND MATRIX DEGRADATION

5. BIOMECHANICS OF JOINTS

Section 2 IMMUNE AND INFLAMMATORY RESPONSES

6. MACROPHAGES,DENDRITIC CELLS,AND FOLLICULAR DENDRITIC CELLS

7. GENETICS OF RHEUMATIC DISEASES

8. T LYMPHOCYTES

9. B CELLS

10. RHEUMATOID FACTOR

11. ANTINUCLEAR ANTIBODIES

12. IMMUNE COMPLEXES

13. COMPLEMENT

14. NEUTROPHILS AND EOSINOPHILS

15. PROSTAGLANDINS,LEUKOTRIENES,AND RELATED COMPOUNDS

16. THE MAST CELL

17. ENDOTHELIAL CELLS AND NITRIC OXIDE

18. PLATELETS

19. FIBROBLAST FUNCTION AND FIBROSIS

20. CYTOKINES

21. APOPTOSIS

22. AUTOMMUNITY

Section 3 EVALUATION OF THE PATIENT

23. EPIDEMIOLOGY OF THE RHEUMATIC DISEASES

24. EVIDENCE-BASED RHEUMATOLOGY

25. EXAMINATION OF THE JOINTS

26. MONARTICULAR ARTHRITIS

27. POLYARTICULAR ARTHRITIS

28. WEAKNESS

29. THE EYE AND RHEUMATIC DISEASE

30. THE SKIN

Section 4 MUSCULOSKELETAL PAIN AND EVALUATION

31. FIBROMYALGIA

32. OCCUPATIONAL AND RECREATIONAL MUSCULOSKELETAL DISORDERS

33. SPORTS MEDICINE

34. NECK PAIN

35. SHOULDER PAIN

36. LOW BACK PAIN

37. HIP AND KNEE PAIN

38. ANKLE AND FOOT PAIN

39. TEMPOROMANDIBULAR JOINT PAIN

40. HAND AND WRIST PAIN

Section 5 DIAGNOSTIC TESTS AND PROCEDURES

41. ASPIRATION AND INJECTION OF JOINTS AND SOFT TISSUES

42. SYNOVIAL FLUID ANALYSIS AND SYNOVIAL BIOPSY

43. IMAGING

44. ARTHROSCOPY AND SYNOVECTOMY

45. LABORATORY EVALUATION OF INFLAMMATION

46. BIOLOGIC MARKERS

Section 6 SPECIAL ISSUES

47. NUTRITION AND RHEUMATIC DISEASES

48. PSYCHOSOCIAL MANAGEMENT OF RHEUMATIC DISEASES

49. GERIATRICS AND THE RHEUMATIC DISEASES

50. ALTERNATIVE CARE FOR ARTHRITIS AND RELATED MUSCULOSKELETAL DISEASES

51. CHRONIC PAIN MANAGEMENT

52. REHABILITATION OF PATIENTS WITH RHEUMATIC DISEASES

53. HEALTH OUTCOME ASSESSMENT

Section 7 CLINICAL PHARMACOLOGY

54. DEVELOPING A CLINICAL TRIAL DESIGN

55. NONSTEROIDAL ANTI-INFLAMMATORY DRUGS

56. GLUCOCORTICOIDS

57. METHOTREXATE

58. SULFASALAZINE

59. ANTIMALARIAL DRUGS

60. GOLD AND PENICILLAMINE

61. IMMUNOREGULATORY DRUGS

62. BIOLOGIC AGENTS FOR THE TREATMENT OF RHEUMATOID ARTHRITIS

63. TETRACYCLINES

INDEX

VOLUME 2

Section 8 RHEUMATOID ARTHRITIS

Section 9 SPONDYLOARTHROPATHIES

Section 10 SYSTEMIC LUPUS ERYTHEMATOSUS AND RELATED SYNDROMES

Section 11 VASCULITIC SYNDROMES

Section 12 SCLERODERMA AND MIXED CONNECTIVE TISSUE DISEASES

Section 13 STRUCTURE,FUNCTION,AND DISEASE OF MUSCLE

Section 14 RHEUMATIC DISEASES OF CHILDHOOD

Section 15 CRYSTAL-ASSOCIATED SYNOVITIS

Section 16 OSTEOARTHRITIS,POLYCHONDRITIS,AND HERITABLE DISORDERS

Section 17 ARTHRITIS RELATED TO INFECTION

Section 18 ARTHRITIS ACCOMPANYING SYSTEMIC DISORDERS

Section 19 DISORDERS OF BONE AND STRUCTURAL PROTEIN

Section 20 TUMORS INVOLVING JOINTS

Section 21 RECONSTRUCTIVE SURGERY FOR RHEUMATIC DISEASE

INDEX

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书籍介绍

More than 20 years ago, in the preface to the first edition of the Textbook of Rheumatology, we suggested that "The field of rheumatology has come of age." What we meant was that rheumatology had shed its strictly empirical base and its host of unproven remedies and become a healing discipline thoroughly grounded in science. We thought it was time for a new textbook, one that reflected this passage through epistemological puberty.

The sixth edition reflects the maturation of rheumatology as a subspecialty. It is instructive to compare the contents of the first and sixth editions. Many chapters have disappeared entirely, and their material has been condensed and incorporated into existing chapters. Consider, for example, that in the basic science section of the first edition we devoted entire chapters to immunoglobulin structure, the contact activation system, and lysosomes (not to mention purine metabolism, a subject dear to the heart of the then senior editor). Cyclic nucleotides and eosinophilic chemotactic factor of anaphylaxis figured prominently in the titles of other basic science chapters. None of these has a place in the Table of Contents of the current edition. Instead, there are chapters dealing with dendritic cells, leukotrienes, mast cells, nitric oxide, fibroblasts, cytokines, and apoptosis. The importance of these topics to understanding the rheumatic diseases was unknown 20 years ago, and some of them hadn't even been discovered! Who can imagine what the scientific basis of rheumatology will be in the 10th edition, 20 years from now? Surely, knowledge obtained from the working through of the human genome will figure prominently.